435 research outputs found
Prospects of a Dusselian Ethics of Liberation among US Minorities: The Case of Affirmative Action in Higher Education
This paper proposes an application of Enrique Dussel’s ethics of liberation to an issue
of crucial importance to US minorities: the debate on affirmative action. Over the past
fifty years, this debate has been framed in terms of the opposition between advocates of affirmative action who claim that it is needed in order to achieve the integration and
participation of traditionally oppressed groups to society without which there is no
equality of rights, and critics who argue that affirmative action violates equality by
enforcing a double standard that undermines the ideal of a color-blind society. In this
paper, I show how the basic principles of Dussel’s ethical theory (which are best
expounded in his book Ethics of Liberation) allow us to address what I take to be the
main demands of both advocates and critics of affirmative action in a satisfactory way
Epistemic Injustice and the Struggle for Recognition of Afro-Mexicans: A Model for Native Americans?
The Foundations of a Mexican Humanism in Emilio Uranga's Análisis del ser del Mexicano
In this paper, I examine the humanism articulated by Jean-Paul Sartre in Existentialism is a humanism and I show that his proposal is underpinned by some problematic assumptions and biases that shape its deployment. I also argue that the Mexican philosopher Emilio Uranga offers us in his most important work, Analísis del Ser del Mexicano, some conceptual resources that allow us to articulate a humanism that does not fall prey to the problems faced by that of Sartr
Measurement of 1323 and 1487 keV resonances in 15N({\alpha}, {\gamma})19F with the recoil separator ERNA
The origin of fluorine is a widely debated issue. Nevertheless, the
^{15}N({\alpha},{\gamma})^{19}F reaction is a common feature among the various
production channels so far proposed. Its reaction rate at relevant temperatures
is determined by a number of narrow resonances together with the DC component
and the tails of the two broad resonances at E_{c.m.} = 1323 and 1487 keV.
Measurement through the direct detection of the 19F recoil ions with the
European Recoil separator for Nuclear Astrophysics (ERNA) were performed. The
reaction was initiated by a 15N beam impinging onto a 4He windowless gas
target. The observed yield of the resonances at Ec.m. = 1323 and 1487 keV is
used to determine their widths in the {\alpha} and {\gamma} channels. We show
that a direct measurement of the cross section of the
^{15}N({\alpha},{\gamma})^{19}F reaction can be successfully obtained with the
Recoil Separator ERNA, and the widths {\Gamma}_{\gamma} and {\Gamma}_{\alpha}
of the two broad resonances have been determined. While a fair agreement is
found with earlier determination of the widths of the 1487 keV resonance, a
significant difference is found for the 1323 keV resonance {\Gamma}_{\alpha} .
The revision of the widths of the two more relevant broad resonances in the
15N({\alpha},{\gamma})19F reaction presented in this work is the first step
toward a more firm determination of the reaction rate. At present, the residual
uncertainty at the temperatures of the ^{19}F stellar nucleosynthesis is
dominated by the uncertainties affecting the Direct Capture component and the
364 keV narrow resonance, both so far investigated only through indirect
experiments.Comment: 8 pages, 11 figures. Accepted for publication in PR
An Influenza A/H1N1/2009 Hemagglutinin Vaccine Produced in Escherichia coli
The A/H1N1/2009 influenza pandemic made evident the need for faster and higher-yield methods for the production of influenza vaccines. Platforms based on virus culture in mammalian or insect cells are currently under investigation. Alternatively, expression of fragments of the hemagglutinin (HA) protein in prokaryotic systems can potentially be the most efficacious strategy for the manufacture of large quantities of influenza vaccine in a short period of time. Despite experimental evidence on the immunogenic potential of HA protein constructs expressed in bacteria, it is still generally accepted that glycosylation should be a requirement for vaccine efficacy.We expressed the globular HA receptor binding domain, referred to here as HA(63-286)-RBD, of the influenza A/H1N1/2009 virus in Escherichia coli using a simple, robust and scalable process. The recombinant protein was refolded and purified from the insoluble fraction of the cellular lysate as a single species. Recombinant HA(63-286)-RBD appears to be properly folded, as shown by analytical ultracentrifugation and bio-recognition assays. It binds specifically to serum antibodies from influenza A/H1N1/2009 patients and was found to be immunogenic, to be capable of triggering the production of neutralizing antibodies, and to have protective activity in the ferret model.Projections based on our production/purification data indicate that this strategy could yield up to half a billion doses of vaccine per month in a medium-scale pharmaceutical production facility equipped for bacterial culture. Also, our findings demonstrate that glycosylation is not a mandatory requirement for influenza vaccine efficacy
The Gaia mission
Gaia is a cornerstone mission in the science programme of the EuropeanSpace Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community focusses on data processing for which the international Gaia Data Processing and Analysis Consortium (DPAC) was selected in 2007. Gaia was launched on 19 December 2013 and arrived at its operating point, the second Lagrange point of the Sun-Earth-Moon system, a few weeks later. The commissioning of the spacecraft and payload was completed on 19 July 2014. The nominal five-year mission started with four weeks of special, ecliptic-pole scanning and subsequently transferred into full-sky scanning mode. We recall the scientific goals of Gaia and give a description of the as-built spacecraft that is currently (mid-2016) being operated to achieve these goals. We pay special attention to the payload module, the performance of which is closely related to the scientific performance of the mission. We provide a summary of the commissioning activities and findings, followed by a description of the routine operational mode. We summarise scientific performance estimates on the basis of in-orbit operations. Several intermediate Gaia data releases are planned and the data can be retrieved from the Gaia Archive, which is available through the Gaia home page. http://www.cosmos.esa.int/gai
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
The original version of this article unfortunately contained a mistake
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